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With the help of West Virginia Senator Jennings Randolph, Congress amended the law in 1974 to exclude signs on farm structures or natural surfaces, or, as in this case, of historic or artistic significance

DNA methylation changes were identified in 11 regions (called CpGs) that were associated with exposure to second-hand smoke

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Despite the name, ENDS are regulated regardless of whether they contain nicotine or are used with nicotine